Pseudodynamics

We represented cellular development as a partial differential equation over gene expression 'space' and developmental time, using time-series snapshot measurements to infer the parameters of the underlying dynamics.

Fischer, D.S., Fiedler, A.K., Kernfeld, E.M. et al. Inferring population dynamics from single-cell RNA-sequencing time series data. Nat Biotechnol 37, 461–468 (2019).

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Computational challenges in spatial omics